Notre Dame was already slated to enter its Fiesta Bowl matchup against Ohio State without its top cornerback, senior KeiVarae Russell.
The Irish secondary lost two more starters on Tuesday.
Junior cornerback Devin Butler was expected to fill Russell's shoes, but will be unable after suffering a fracture in the fifth metatarsal of his left foot at Monday's practice, Brian Kelly announced Tuesday. Sophomore Nick Watkins will start in his place.
Starting junior safety Max Redfield, a former five-star recruit whom 11W film analyst Kyle Jones called "above average" in coverage, will also miss the Fiesta Bowl after violating team rules.
The Irish will enter the New Year's Day bowl with the nation's 37th-ranked pass defense.
