The Buckeyes will be a 2.5-point road favorite when they take on Creighton in Omaha on Thursday night, according to VegasInsider.com.
This is already Ohio State's second game against a 2018 NCAA Tournament team after the Buckeyes handled Cincinnati on the road to start the season.
Ohio State was a 5.5-point underdog in that road contest against the Bearcats, but got the win outright.
Both Ohio State and Creighton are off to a 2-0 start looking to get a quality non-conference win to kick off the season.