In a battle of unbeaten squads, No. 4 Ohio State opened as a 4.5 point favorite over No. 9 Penn State, but the spread dropped to -3.5 shortly thereafter, according to VegasInsider.com.
The game features two of the nation's best offenses from a statistical perspective, as Penn State leads the country scoring 55.5 points per game while Ohio State ranks No. 2 at 54.5 points per contest.
The Buckeyes have won five of the last six matchups between the schools, including a 39-38 thriller last season in Columbus.
Ohio State leads the all-time series 18-14.
The 7:30 p.m. kickoff in Beaver Stadium will be televised on ABC.