Looking at the way the bracket shakes out, now that we have the first CFP rankings, it's pretty interesting to contemplate where you want to be ranked. 

The first CFP bracket projection with the 12-team playoff era has dropped pic.twitter.com/HXK3syhbEE
— ESPN (@espn) November 6, 2024

Because the #5 seed is always going to be the best Big Ten or SEC team that did not win its conference, it is likely to be a team you don't want to play. If you are the 1 seed, you probably are playing a good/not great team in the quarters, and probably the 5 seed, and not the 4 seed, most years in the semifinals. 

If you are the 2 seed, you are playing a different good/not great team in the quarters, and you are either playing the 3 seed (the best of the Big 12 or ACC) or the 6 seed in the semis. I would bet most years, the 5 seed is going to be better than the 3 seed (and the committee already decided it's better than the 6 seed). So your path to the finals is better as the 2 seed than the 1 seed.