Don't be surprised if Indiana does that. VT did it and it caught the O by surprise and they had no answers. 

Or....

A bull rush right up the middle will test the cohesiveness of the center's skills. 

In either case, I expect the Buckeye O to either hit the permitter or center of the field on quick passes and thus exploit their D's aggressive play, scoring in bunches and quickly; or, for the O to be confused, have to adjust at half, and wins a close one. It would not surprise me to see them behind at the half.