Ohio State has opened as a 22.5-point favorite for Saturday's home game (12 p.m., FOX) against Nebraska, according to Vegas Insider.
Coming off a loss to Purdue and a bye week, the Buckeyes (7-1) will be looking to get back into the win column against the Cornhuskers (2-6), who lost their first six games of the year but have won their last two.
Ohio State defeated Nebraska by a score of 56-14 at Nebraska last year. That said, the Buckeyes are 0-4 against the spread in their last four games, and have only barely won one of their last four games by more than 22.5 points (49-26 over Indiana on Oct. 6).