| SAT AUG 31 3:30 PM |  Akron | Ohio StadiumColumbus, OH | CBS | W, 52–6 |
| SAT SEP 7 7:30 PM |  Western Michigan | Ohio StadiumColumbus, OH | BTN | W, 56–0 |
| SAT SEP 21 NOON |  Marshall | Ohio StadiumColumbus, OH | FOX | W, 49–14 |
| SAT SEP 28 7:30 PM |  Michigan State | Spartan StadiumEast Lansing, MI | Peacock | W, 38–7 |
| SAT OCT 5 3:30 PM |  Iowa | Ohio StadiumColumbus, OH | CBS | W, 35–7 |
| SAT OCT 12 7:30 PM |  #3 Oregon | Autzen StadiumEugene, OR | NBC | L, 31–32 |
| SAT OCT 26 NOON |  Nebraska | Ohio StadiumColumbus, OH | FOX | W, 21–17 |
| SAT NOV 2 NOON |  #3 Penn State | Beaver StadiumUniversity Park, PA | FOX | W, 20–13 |
| SAT NOV 9 NOON |  Purdue | Ohio StadiumColumbus, OH | FOX | W, 45–0 |
| SAT NOV 16 NOON |  Northwestern | Wrigley FieldChicago, IL | BTN | W, 31–7 |
| SAT NOV 23 NOON |  #5 Indiana | Ohio StadiumColumbus, OH | FOX | W, 38–15 |
| SAT NOV 30 NOON |  Michigan | Ohio StadiumColumbus, OH | FOX | L, 10–13 |
| College Football Playoff First Round | ||||
| SAT DEC 21 8:00 PM |  #9 Tennessee | Ohio StadiumColumbus, OH | ESPN/ABC | W, 42–17 |
| College Football Playoff Quarterfinals | ||||
| WED JAN 1 5:00 PM | #1 Oregon | Rose BowlPasadena, CA | ESPN | W, 41–21 |
| College Football Playoff Semifinals | ||||
| FRI JAN 10 7:30 PM |  #5 Texas | Cotton BowlArlington, TX | ESPN | W, 28–14 |
| College Football Playoff National Championship | ||||
| MON JAN 20 7:30 PM |  #7 Notre Dame | Mercedes Benz StadiumAtlanta, GA | ESPN | W, 34–23 |
