Penn State led 28-20 with less than two minutes to go, but a late touchdown drive orchestrated by Indiana quarterback Michael Penix Jr. forced overtime, where the Hoosiers prevailed 36-35.
Penn State running back Journey Brown, the Nittany Lions' leading rusher last year, could miss the 2020 season while undergoing treatment for a medical condition discovered during the offseason.
Nick Saban received three negative COVID-19 tests in three days, clearing his return to the sideline for his Crimson Tide's clash with No. 3 Georgia Saturday night.
Minnesota wide receiver Rashod Bateman will be back to play for the Gophers this fall, but Penn State linebacker Micah Parsons won't be returning to the Nittany Lions.